InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: P4HA1

Summary

InnateDB Gene

IDBG-630046.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P4HA1

Gene Name

Prolyl 4-hydroxylase subunit alpha-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000032996

Encoded Proteins

IDBP-681492

Prolyl 4-hydroxylase subunit alpha-1

IDBP-681494

Prolyl 4-hydroxylase subunit alpha-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122884:
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:29229501-29329487

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000046841	ENSBTAP00000044089
ENSBTAT00000056188	ENSBTAP00000048870

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004656	procollagen-proline 4-dioxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0019511	peptidyl-proline hydroxylation
GO:0030199	collagen fibril organization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0016020	membrane
GO:0016222	procollagen-proline 4-dioxygenase complex
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000122884

View Gene Order

ENSMUSG00000019916

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00330

Arginine and proline metabolism pathway

mmu00330

Arginine and proline metabolism pathway

INOH

INOH website

Arginine Proline metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.41027 Bt.89302

RefSeq

NM_001075770 XM_005226386 XM_005226387 XM_005226388 XM_005226389

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas