InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: COX4I1

Summary

InnateDB Gene

IDBG-630164.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COX4I1

Gene Name

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Synonyms

COX4

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016079

Encoded Proteins

IDBP-681600

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

IDBP-681602

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131143:
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. [provided by RefSeq, Jul 2008]
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3\' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:11799175-11807341

Strand

Forward strand

Band

Transcripts

ENSBTAT00000053881	ENSBTAP00000049613
ENSBTAT00000021397	ENSBTAP00000021397

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004129	cytochrome-c oxidase activity
GO:0005515	protein binding

Biological Process

GO:1902600

hydrogen ion transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005751	mitochondrial respiratory chain complex IV
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045277	respiratory chain complex IV
GO:0070062	extracellular vesicular exosome