Homo sapiens Gene: MRC2
Summary
InnateDB Gene IDBG-63031.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRC2
Gene Name mannose receptor, C type 2
Synonyms CD280; CLEC13E; ENDO180; UPARAP;
Species Homo sapiens
Ensembl Gene ENSG00000011028
Encoded Proteins
mannose receptor, C type 2
mannose receptor, C type 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:62627401-62693597
Strand Forward strand
Band q23.2
Transcripts
ENST00000303375 ENSP00000307513
ENST00000446119 ENSP00000400445
ENST00000583597
ENST00000579432 ENSP00000463968
ENST00000584682 ENSP00000461968
ENST00000580916
ENST00000584265
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0030246 carbohydrate binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006897 endocytosis
GO:0030574 collagen catabolic process
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Cross-presentation of soluble exogenous antigens (endosomes) pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
Phagosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL J3QQZ6
UniProt Splice Variant
Entrez Gene 9902
UniGene Hs.7835
RefSeq NM_006039
HUGO HGNC:16875
OMIM 612264
CCDS CCDS11634
HPRD 10094
IMGT
EMBL AC080038
GenPept
RNA Seq Atlas 9902