Version 5.4
Homo sapiens Gene: MRC2
Summary
InnateDB Gene IDBG-63031.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRC2
Gene Name mannose receptor, C type 2
Synonyms CD280; CLEC13E; ENDO180; UPARAP
Species Homo sapiens
Ensembl Gene ENSG00000011028
Encoded Proteins
IDBP-63033
mannose receptor, C type 2
IDBP-382804
mannose receptor, C type 2
IDBP-760372
IDBP-764635
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:62627401-62693597
Strand Forward strand
Band q23.2
Transcripts
ENST00000303375 ENSP00000307513
ENST00000446119 ENSP00000400445
ENST00000583597
ENST00000579432 ENSP00000463968
ENST00000584682 ENSP00000461968
ENST00000580916
ENST00000584265
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0030246 carbohydrate binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006897 endocytosis
GO:0030574 collagen catabolic process
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020695
View Gene Order
ENSBTAG00000015739
Not yet available
Pathways
NETPATH
REACTOME
REACT_111056
Cross-presentation of soluble exogenous antigens (endosomes) pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 9902
UniGene Hs.7835
RefSeq NM_006039
HUGO HGNC:16875
OMIM 612264
CCDS CCDS11634
HPRD 10094
IMGT
EMBL
GenPept
RNA Seq Atlas 9902

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca