InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MRC2

Summary

InnateDB Protein

IDBP-63033.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MRC2

Protein Name

mannose receptor, C type 2

Synonyms

CD280; CLEC13E; ENDO180; UPARAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000307513

InnateDB Gene

IDBG-63031 (MRC2)

Protein Structure

UniProt Annotation

Function

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). {ECO:0000269PubMed:10683150, ECO:0000269PubMed:12972549}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. {ECO:0000269PubMed:10683150, ECO:0000269PubMed:8702911}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0030246	carbohydrate binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006897	endocytosis
GO:0030574	collagen catabolic process

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000562 Fibronectin, type II, collagen-binding
IPR000772 Ricin B lectin domain
IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR008646 Herpesvirus UL45-like
IPR013806 Kringle-like fold
IPR016187 C-type lectin fold

PFAM

PF00040
PF00652
PF14200
PF00059
PF05473

PRINTS

PR00356

PIRSF

SMART

SM00059
SM00458
SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt