InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TPD52L1

Summary

InnateDB Gene

IDBG-630484.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPD52L1

Gene Name

tumor protein D53

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003336

Encoded Proteins

IDBP-681942

tumor protein D52-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111907:
This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:26310580-26403759

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000004332

ENSBTAP00000004332

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043406	positive regulation of MAP kinase activity
GO:0046330	positive regulation of JNK cascade
GO:2001235	positive regulation of apoptotic signaling pathway