Version 5.4
Homo sapiens Gene: TPD52L1
Summary
InnateDB Gene IDBG-96106.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPD52L1
Gene Name tumor protein D52-like 1
Synonyms D53; hD53
Species Homo sapiens
Ensembl Gene ENSG00000111907
Encoded Proteins
IDBP-96108
tumor protein D52-like 1
IDBP-96112
tumor protein D52-like 1
IDBP-96114
tumor protein D52-like 1
IDBP-245571
tumor protein D52-like 1
IDBP-601178
tumor protein D52-like 1
IDBP-590557
tumor protein D52-like 1
IDBP-603193
tumor protein D52-like 1
IDBP-593710
tumor protein D52-like 1
IDBP-595804
tumor protein D52-like 1
IDBP-591538
tumor protein D52-like 1
IDBP-588323
tumor protein D52-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:125119049-125264407
Strand Forward strand
Band q22.31
Transcripts
ENST00000368402 ENSP00000357387
ENST00000304877 ENSP00000306285
ENST00000368388 ENSP00000357373
ENST00000392483
ENST00000392482 ENSP00000376273
ENST00000534368 ENSP00000432806
ENST00000534000 ENSP00000434142
ENST00000527711 ENSP00000436953
ENST00000528193 ENSP00000434743
ENST00000532978
ENST00000532429 ENSP00000435447
ENST00000534199 ENSP00000432590
ENST00000524679 ENSP00000432787
ENST00000532423
ENST00000530868
ENST00000571678
ENST00000576089
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0046330 positive regulation of JNK cascade
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000296
View Gene Order
ENSBTAG00000003336
Not yet available
Pathways
NETPATH
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q16890
TrEMBL E9PNQ9
UniProt Splice Variant
Entrez Gene 7164
UniGene Hs.591347 Hs.665091
RefSeq NM_001003395 NM_001003396 NM_001003397 NM_001300994 NM_003287 XM_005267121 XM_005267122 XM_005267123 XM_006715557
HUGO HGNC:12006
OMIM 604069
CCDS CCDS75514 CCDS34527 CCDS34528 CCDS43502 CCDS5130 CCDS75513
HPRD 07236
IMGT
EMBL AF004427 AF208012 AK291866 AK291872 AK291887 AL121938 AL136128 BC002375 CH471051 U44427 U44428
GenPept AAB40894 AAB40895 AAC98475 AAG49634 AAH02375 BAF84555 BAF84561 BAF84576 CAI19645 CAI19647 CAI19648 CAI19649 CAI23002 CAI23003 CAI23004 EAW48142
RNA Seq Atlas 7164

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca