InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GUCA1A

Summary

InnateDB Gene

IDBG-631038.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUCA1A

Gene Name

Guanylyl cyclase-activating protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012823

Encoded Proteins

IDBP-682537

Guanylyl cyclase-activating protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000048545:
This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:15901126-15908139

Strand

Forward strand

Band

Transcripts

ENSBTAT00000017036

ENSBTAP00000017036

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008048	calcium sensitive guanylate cyclase activator activity
GO:0030249	guanylate cyclase regulator activity
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0031282	regulation of guanylate cyclase activity
GO:0031284	positive regulation of guanylate cyclase activity
GO:0050896	response to stimulus