Version 5.4
Bos taurus Protein: GUCA1A
Summary
InnateDB Protein IDBP-682537.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GUCA1A
Protein Name Guanylyl cyclase-activating protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017036
InnateDB Gene IDBG-631038 (GUCA1A)
Protein Structure
UniProt Annotation
Function Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.
Subcellular Localization Membrane; Lipid-anchor.
Disease Associations
Tissue Specificity Retina; rod and cone cells. Also present in certain pinealocytes. {ECO:0000269PubMed:10821676}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008048 calcium sensitive guanylate cyclase activator activity
GO:0030249 guanylate cyclase regulator activity
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0031282 regulation of guanylate cyclase activity
GO:0031284 positive regulation of guanylate cyclase activity
GO:0050896 response to stimulus
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
IPR019577 SPARC/Testican, calcium-binding domain
PFAM PF00036
PF13202
PF13405
PF10591
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P46065
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282243
UniGene Bt.178
RefSeq NP_776971
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL S74247 X95352
GenPept AAB31698 CAA64642

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca