Version 5.4
Bos taurus Gene: FHL1
Summary
InnateDB Gene IDBG-631156.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FHL1
Gene Name four and a half LIM domains protein 1 isoform 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018513
Encoded Proteins
IDBP-682669
four and a half LIM domains 1 isoform 1
IDBP-682674
four and a half LIM domains 1 isoform 1
IDBP-682678
four and a half LIM domains 1 isoform 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000022267:
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:19777799-19820952
Strand Forward strand
Band
Transcripts
ENSBTAT00000063425 ENSBTAP00000054891
ENSBTAT00000024644 ENSBTAP00000024644
ENSBTAT00000024641 ENSBTAP00000024641
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044325 ion channel binding
GO:0046872 metal ion binding
Biological Process
GO:0003254 regulation of membrane depolarization
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0030308 negative regulation of cell growth
GO:0043268 positive regulation of potassium ion transport
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000022267
View Gene Order
ENSMUSG00000023092
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.23401
RefSeq NM_001034341 NM_001113258 NM_001113259
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca