Version 5.4
Bos taurus Gene: CDC42BPA
Summary
InnateDB Gene IDBG-631163.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC42BPA
Gene Name serine/threonine-protein kinase MRCK alpha
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000022777
Encoded Proteins
IDBP-682689
CDC42 binding protein kinase alpha (DMPK-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143776:
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30708032-31000733
Strand Reverse strand
Band
Transcripts
ENSBTAT00000029173 ENSBTAP00000029173
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006468 protein phosphorylation
GO:0007097 nuclear migration
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0031032 actomyosin structure organization
GO:0031532 actin cytoskeleton reorganization
GO:0035556 intracellular signal transduction
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0042641 actomyosin
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000143776
View Gene Order
ENSMUSG00000026490
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
cdc42_pathway
CDC42 signaling events
Cross-References
SwissProt
TrEMBL F1MH45
UniProt Splice Variant
Entrez Gene 538392
UniGene Bt.91177
RefSeq NM_001192937
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02042679 DAAA02042680 DAAA02042681 DAAA02042682 DAAA02042683 DAAA02042684
GenPept
RNA Seq Atlas 538392

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca