Version 5.4
Homo sapiens Gene: CDC42BPA
Summary
InnateDB Gene IDBG-107075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC42BPA
Gene Name CDC42 binding protein kinase alpha (DMPK-like)
Synonyms MRCK; MRCKA; PK428
Species Homo sapiens
Ensembl Gene ENSG00000143776
Encoded Proteins
IDBP-107077
CDC42 binding protein kinase alpha (DMPK-like)
IDBP-107079
CDC42 binding protein kinase alpha (DMPK-like)
IDBP-107081
CDC42 binding protein kinase alpha (DMPK-like)
IDBP-107083
CDC42 binding protein kinase alpha (DMPK-like)
IDBP-107087
CDC42 binding protein kinase alpha (DMPK-like)
IDBP-390091
CDC42 binding protein kinase alpha (DMPK-like)
IDBP-390092
CDC42 binding protein kinase alpha (DMPK-like)
IDBP-390093
CDC42 binding protein kinase alpha (DMPK-like)
IDBP-390094
CDC42 binding protein kinase alpha (DMPK-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:226989865-227318474
Strand Reverse strand
Band q42.13
Transcripts
ENST00000366769 ENSP00000355731
ENST00000366767 ENSP00000355729
ENST00000334218 ENSP00000335341
ENST00000366766 ENSP00000355728
ENST00000366764 ENSP00000355726
ENST00000448940 ENSP00000415388
ENST00000442054 ENSP00000401051
ENST00000429440 ENSP00000407120
ENST00000441725 ENSP00000408165
ENST00000488131
ENST00000466538
ENST00000478573
ENST00000462553
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006468 protein phosphorylation
GO:0007097 nuclear migration
GO:0016477 cell migration
GO:0031032 actomyosin structure organization
GO:0031532 actin cytoskeleton reorganization
GO:0035556 intracellular signal transduction
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0031252 cell leading edge
GO:0042641 actomyosin
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026490
View Gene Order
ENSBTAG00000022777
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
cdc42_pathway
CDC42 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.35433 Hs.604610 Hs.605778 Hs.623470
RefSeq NM_003607 NM_014826 XM_005273321 XM_005273322 XM_005273324
HUGO
OMIM
CCDS CCDS1558 CCDS1559
HPRD 04562
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca