Bos taurus Gene: TARBP2
Summary
InnateDB Gene IDBG-631247.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TARBP2
Gene Name RISC-loading complex subunit TARBP2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000435
Encoded Proteins
RISC-loading complex subunit TARBP2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139546:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:26681522-26686845
Strand Forward strand
Band
Transcripts
ENSBTAT00000000558 ENSBTAP00000000558
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0035197 siRNA binding
GO:0035198 miRNA binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006417 regulation of translation
GO:0030422 production of siRNA involved in RNA interference
GO:0030423 targeting of mRNA for destruction involved in RNA interference
GO:0031047 gene silencing by RNA
GO:0031054 pre-miRNA processing
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0045070 positive regulation of viral genome replication
GO:0046782 regulation of viral transcription
GO:0050689 negative regulation of defense response to virus by host
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016442 RISC complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MicroRNA (miRNA) biogenesis pathway
Gene Expression pathway
Small interfering RNA (siRNA) biogenesis pathway
Regulatory RNA pathways pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
MicroRNA (miRNA) biogenesis pathway
Small interfering RNA (siRNA) biogenesis pathway
Gene Expression pathway
Regulatory RNA pathways pathway
MicroRNA (miRNA) biogenesis pathway
Gene Expression pathway
Regulatory RNA pathways pathway
Small interfering RNA (siRNA) biogenesis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q0IIG6
TrEMBL
UniProt Splice Variant
Entrez Gene 514674
UniGene Bt.4728
RefSeq NM_001075678
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122653 CK769751
GenPept AAI22654
RNA Seq Atlas 514674
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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