Mus musculus Gene: Tarbp2
Summary
InnateDB Gene IDBG-188971.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tarbp2
Gene Name TAR (HIV) RNA binding protein 2
Synonyms Prbp; TRBP;
Species Mus musculus
Ensembl Gene ENSMUSG00000023051
Encoded Proteins
TAR (HIV) RNA binding protein 2
TAR (HIV) RNA binding protein 2
TAR (HIV) RNA binding protein 2
TAR (HIV) RNA binding protein 2
TAR (HIV) RNA binding protein 2
TAR (HIV) RNA binding protein 2
TAR (HIV) RNA binding protein 2
TAR (HIV) RNA binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139546:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:102518192-102523676
Strand Forward strand
Band F3
Transcripts
ENSMUST00000100168 ENSMUSP00000097744
ENSMUST00000023813 ENSMUSP00000023813
ENSMUST00000131184 ENSMUSP00000117964
ENSMUST00000141266
ENSMUST00000136968
ENSMUST00000150393 ENSMUSP00000120315
ENSMUST00000154451
ENSMUST00000142114 ENSMUSP00000114953
ENSMUST00000154948
ENSMUST00000134033
ENSMUST00000146756 ENSMUSP00000121748
ENSMUST00000149200 ENSMUSP00000123213
ENSMUST00000142194 ENSMUSP00000123339
ENSMUST00000153171
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0035197 siRNA binding
GO:0035198 miRNA binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006417 regulation of translation
GO:0030422 production of siRNA involved in RNA interference
GO:0030423 targeting of mRNA for destruction involved in RNA interference
GO:0031054 pre-miRNA processing
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0045070 positive regulation of viral genome replication
GO:0046782 regulation of viral transcription
GO:0050689 negative regulation of defense response to virus by host
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016442 RISC complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MicroRNA (miRNA) biogenesis pathway
Gene Expression pathway
Regulatory RNA pathways pathway
Small interfering RNA (siRNA) biogenesis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
MicroRNA (miRNA) biogenesis pathway
Small interfering RNA (siRNA) biogenesis pathway
Gene Expression pathway
Regulatory RNA pathways pathway
MicroRNA (miRNA) biogenesis pathway
Gene Expression pathway
Small interfering RNA (siRNA) biogenesis pathway
Regulatory RNA pathways pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P97473
TrEMBL D3YUS9 D3YZS5 D3Z033 D3Z282 D6RCY4 D6RE49 Q3UNH9
UniProt Splice Variant
Entrez Gene 21357
UniGene Mm.291485
RefSeq NM_001253795 NM_009319 XM_006520719 XM_006520721 XM_006520724
OMIM
CCDS CCDS27886 CCDS57013
HPRD
IMGT
MGI ID MGI:103027
MGI Symbol Tarbp2
EMBL AC137156 AK144205 BC002028 CH466550 U79962
GenPept AAB38885 AAH02028 BAE25768 EDL03967
RNA Seq Atlas 21357