Bos taurus Gene: CD3E
Summary
InnateDB Gene IDBG-631260.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD3E
Gene Name T-cell surface glycoprotein CD3 epsilon chain
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015710
Encoded Proteins
T-cell surface glycoprotein CD3 epsilon chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198851:
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:29441565-29452179
Strand Forward strand
Band
Transcripts
ENSBTAT00000020859 ENSBTAP00000020859
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002669 positive regulation of T cell anergy
GO:0007166 cell surface receptor signaling pathway
GO:0031295 T cell costimulation
GO:0032729 positive regulation of interferon-gamma production
GO:0032753 positive regulation of interleukin-4 production
GO:0042102 positive regulation of T cell proliferation
GO:0045060 negative thymic T cell selection
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045879 negative regulation of smoothened signaling pathway
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0046649 lymphocyte activation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042101 T cell receptor complex
GO:0042105 alpha-beta T cell receptor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
PD-1 signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Costimulation by the CD28 family pathway
Downstream TCR signaling pathway
Immune System pathway
Adaptive Immune System pathway
Generation of second messenger molecules pathway
Translocation of ZAP-70 to Immunological synapse pathway
TCR signaling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
Prolactin pathway
REACTOME
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Downstream TCR signaling pathway
Generation of second messenger molecules pathway
Translocation of ZAP-70 to Immunological synapse pathway
Phosphorylation of CD3 and TCR zeta chains pathway
PD-1 signaling pathway
Costimulation by the CD28 family pathway
TCR signaling pathway
Adaptive Immune System pathway
Immune System pathway
PD-1 signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Downstream TCR signaling pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Immune System pathway
Translocation of ZAP-70 to Immunological synapse pathway
Costimulation by the CD28 family pathway
Adaptive Immune System pathway
Generation of second messenger molecules pathway
TCR signaling pathway
KEGG
Hematopoietic cell lineage pathway
T cell receptor signaling pathway pathway
Primary immunodeficiency pathway
Chagas disease (American trypanosomiasis) pathway
Hematopoietic cell lineage pathway
T cell receptor signaling pathway pathway
Primary immunodeficiency pathway
Chagas disease (American trypanosomiasis) pathway
INOH
CD4 T cell receptor signaling pathway
CD4 T cell receptor signaling pathway
PID NCI
TCR signaling in naïve CD8+ T cells
CXCR4-mediated signaling events
TCR signaling in naïve CD4+ T cells
Downstream signaling in naïve CD8+ T cells
IL12-mediated signaling events
IL12 signaling mediated by STAT4
IL23-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.49707
RefSeq NM_174011 XM_005215798
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas