Homo sapiens Gene: CD3E
Summary
InnateDB Gene IDBG-73617.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD3E
Gene Name CD3e molecule, epsilon (CD3-TCR complex)
Synonyms IMD18; T3E; TCRE;
Species Homo sapiens
Ensembl Gene ENSG00000198851
Encoded Proteins
CD3e molecule, epsilon (CD3-TCR complex)
CD3e molecule, epsilon (CD3-TCR complex)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:118304545-118316175
Strand Forward strand
Band q23.3
Transcripts
ENST00000361763 ENSP00000354566
ENST00000529713
ENST00000528435
ENST00000526146
ENST00000528600 ENSP00000433975
ENST00000531913
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0030159 receptor signaling complex scaffold activity
GO:0042608 T cell receptor binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002669 positive regulation of T cell anergy
GO:0006461 protein complex assembly
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007172 signal complex assembly
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007584 response to nutrient
GO:0031295 T cell costimulation
GO:0032729 positive regulation of interferon-gamma production
GO:0032753 positive regulation of interleukin-4 production
GO:0033077 T cell differentiation in thymus
GO:0035556 intracellular signal transduction
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0042981 regulation of apoptotic process
GO:0045060 negative thymic T cell selection
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045879 negative regulation of smoothened signaling pathway
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0046649 lymphocyte activation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0042101 T cell receptor complex
GO:0042105 alpha-beta T cell receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
Prolactin pathway
REACTOME
PD-1 signaling pathway
TCR signaling pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
Downstream TCR signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Generation of second messenger molecules pathway
Costimulation by the CD28 family pathway
Translocation of ZAP-70 to Immunological synapse pathway
KEGG
Hematopoietic cell lineage pathway
T cell receptor signaling pathway pathway
Chagas disease (American trypanosomiasis) pathway
Primary immunodeficiency pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
The co-stimulatory signal during t-cell activation [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Lck and fyn tyrosine kinases in initiation of tcr activation [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
PID NCI
TCR signaling in na´ve CD8+ T cells
CXCR4-mediated signaling events
TCR signaling in na´ve CD4+ T cells
Downstream signaling in na´ve CD8+ T cells
IL12-mediated signaling events
IL12 signaling mediated by STAT4
IL23-mediated signaling events
Cross-References
SwissProt
TrEMBL A0N2Z5 E9PSH8
UniProt Splice Variant
Entrez Gene 916
UniGene Hs.692065
RefSeq NM_000733
HUGO HGNC:1674
OMIM 186830
CCDS CCDS31685
HPRD 08923
IMGT
EMBL AP001582 M22057
GenPept AAA61062
RNA Seq Atlas 916