InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD3E

Summary

InnateDB Gene

IDBG-73617.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD3E

Gene Name

CD3e molecule, epsilon (CD3-TCR complex)

Synonyms

IMD18; T3E; TCRE

Species

Homo sapiens

Ensembl Gene

ENSG00000198851

Encoded Proteins

IDBP-73619

CD3e molecule, epsilon (CD3-TCR complex)

IDBP-590562

CD3e molecule, epsilon (CD3-TCR complex)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:118304545-118316175

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000361763	ENSP00000354566
ENST00000529713
ENST00000528435
ENST00000526146
ENST00000528600	ENSP00000433975
ENST00000531913

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0030159	receptor signaling complex scaffold activity
GO:0042608	T cell receptor binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002669	positive regulation of T cell anergy
GO:0006461	protein complex assembly
GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007172	signal complex assembly
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007584	response to nutrient
GO:0031295	T cell costimulation
GO:0032729	positive regulation of interferon-gamma production
GO:0032753	positive regulation of interleukin-4 production
GO:0033077	T cell differentiation in thymus
GO:0035556	intracellular signal transduction
GO:0042102	positive regulation of T cell proliferation
GO:0042110	T cell activation
GO:0042981	regulation of apoptotic process
GO:0045060	negative thymic T cell selection
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045879	negative regulation of smoothened signaling pathway
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0046649	lymphocyte activation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776	regulation of immune response
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050852	T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0042101	T cell receptor complex
GO:0042105	alpha-beta T cell receptor complex