Version 5.4
Bos taurus Gene: NOS2
Summary
InnateDB Gene IDBG-631501.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOS2
Gene Name nitric oxide synthase, inducible
Synonyms iNOS; NOS2A
Species Bos taurus
Ensembl Gene ENSBTAG00000006894
Encoded Proteins
IDBP-683052
nitric oxide synthase, inducible
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20157607
[Homo sapiens] NOS2 is a nitric oxide synthase (iNOS) protein and combined treatment with 1,25-dihydroxyvitamin D3 (1,25-D3) and IFN-gamma has been shown to synergistically enhance NO synthesis and NOS2 expression induced by Mycobacterium tuberculosis (MTB) or by its purified protein derivatives in human monocyte-derived macrophages.
PMID 18799752
[Homo sapiens] NOS2 is an inducible nitric oxide (NO) synthase present in innate immune cells that produces NO in response to certain infections or upon stimulation with cytokines such as IFN-gamma and TNF. For optimal induction of NOS2 during Chlamydophila pneumoniae infection, the concerted action of the MyD88-dependent transcription factors NF-kappaB and AP-1 and of the MyD88-independent transcription factors phosphorylated STAT1 and IRF1 is required.
PMID 16893173
[Homo sapiens] NOS2 (iNOS) and CALM1 (CaM) coordinately function to form a stable complex that is part of a rapid host response that functions within the first 30 min following bacterial infection to up-regulate the innate immune system involving macrophage activation.
PMID 22542147
[Homo sapiens] Nitric oxide production by NOS2 promotes Listeria monocytogenes dissemination in the host. (Demonstrated in mice)
PMID 16893173
[Mus musculus] Nos2 (iNOS) and Calm1 (CaM) coordinately function to form a stable complex that is part of a rapid host response that functions within the first 30 min following bacterial infection to upregulate the innate immune system involving macrophage activation.
PMID 22542147
[Mus musculus] Nitric oxide production by Nos2 promotes Listeria monocytogenes dissemination in the host.
PMID 24040305
[Mus musculus] Inorganic polyphosphate suppresses Nos2 expression and nitric oxide release but not TNF release in LPS-activated macrophages
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000007171:
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:19758764-19956549
Strand Reverse strand
Band
Transcripts
ENSBTAT00000009062 ENSBTAP00000009062
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 174 interaction(s) predicted by orthology.
Predicted by orthology
Total 174 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003958 NADPH-hemoprotein reductase activity
GO:0004517 nitric-oxide synthase activity
GO:0005102 receptor binding
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0034617 tetrahydrobiopterin binding
GO:0034618 arginine binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0001666 response to hypoxia
GO:0006527 arginine catabolic process
GO:0006801 superoxide metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0006954 inflammatory response
GO:0007263 nitric oxide mediated signal transduction
GO:0007623 circadian rhythm
GO:0010629 negative regulation of gene expression
GO:0018119 peptidyl-cysteine S-nitrosylation
GO:0031284 positive regulation of guanylate cyclase activity
GO:0032496 response to lipopolysaccharide
GO:0042127 regulation of cell proliferation
GO:0042177 negative regulation of protein catabolic process
GO:0042742 defense response to bacterium
GO:0045776 negative regulation of blood pressure
GO:0045909 positive regulation of vasodilation
GO:0050796 regulation of insulin secretion
GO:0051712 positive regulation of killing of cells of other organism
GO:0055114 oxidation-reduction process
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to interferon-gamma
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0030863 cortical cytoskeleton
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000007171
View Gene Order
ENSMUSG00000020826
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23862
Nitric oxide stimulates guanylate cyclase pathway
REACT_23876
Platelet homeostasis pathway
REACT_121256
Phagosomal maturation (early endosomal stage) pathway
REACT_121237
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
REACT_189085
Disease pathway
REACT_208483
Platelet homeostasis pathway
REACT_224553
Hemostasis pathway
REACT_198345
Phagosomal maturation (early endosomal stage) pathway
REACT_198347
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_245499
Nitric oxide stimulates guanylate cyclase pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa05222
Small cell lung cancer pathway
hsa04020
Calcium signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04146
Peroxisome pathway
hsa05140
Leishmaniasis pathway
hsa05146
Amoebiasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa05145
Toxoplasmosis pathway
mmu04020
Calcium signaling pathway pathway
mmu00330
Arginine and proline metabolism pathway
mmu05222
Small cell lung cancer pathway
mmu05200
Pathways in cancer pathway
mmu04146
Peroxisome pathway
mmu05140
Leishmaniasis pathway
mmu05146
Amoebiasis pathway
mmu05145
Toxoplasmosis pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
Arginine Proline metabolism pathway
PID NCI
il12_2pathway
IL12-mediated signaling events
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
atf2_pathway
ATF-2 transcription factor network
il23pathway
IL23-mediated signaling events
hif1_tfpathway
HIF-1-alpha transcription factor network
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL F1MYR5 Q6ZXD5 Q9BDP5 Q9BDQ7
UniProt Splice Variant
Entrez Gene 282876
UniGene Bt.23126
RefSeq NM_001076799
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF333248 AF340236 AJ699400 DAAA02048556 DAAA02048557 DAAA02048558 DAAA02048559 DAAA02048560 DAAA02048561 DAAA02048562 DAAA02048563 DAAA02048564 DAAA02048565 DAAA02048566
GenPept AAK21212 AAK26383 CAG27866
RNA Seq Atlas 282876

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca