Homo sapiens Gene: GFM1
Summary
InnateDB Gene IDBG-63156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GFM1
Gene Name G elongation factor, mitochondrial 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168827
Encoded Proteins
G elongation factor, mitochondrial 1
G elongation factor, mitochondrial 1
G elongation factor, mitochondrial 1
G elongation factor, mitochondrial 1
G elongation factor, mitochondrial 1
G elongation factor, mitochondrial 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:158644278-158692575
Strand Forward strand
Band q25.32
Transcripts
ENST00000264263 ENSP00000264263
ENST00000312756
ENST00000486715 ENSP00000419038
ENST00000478576 ENSP00000418755
ENST00000478254 ENSP00000417225
ENST00000464732 ENSP00000417532
ENST00000478251
ENST00000490261
ENST00000477721
ENST00000481468
ENST00000472383 ENSP00000420272
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006414 translational elongation
GO:0070125 mitochondrial translational elongation
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation elongation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518355 Hs.686542
RefSeq NM_024996
HUGO
OMIM
CCDS CCDS33885
HPRD 07365
IMGT
EMBL
GenPept
RNA Seq Atlas