Homo sapiens Protein: GFM1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-476890.3 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | GFM1 | ||||||||||||||||||
Protein Name | G elongation factor, mitochondrial 1 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000419038 | ||||||||||||||||||
InnateDB Gene | IDBG-63156 (GFM1) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. {ECO:0000255HAMAP-Rule:MF_03061, ECO:0000269PubMed:19716793}. | ||||||||||||||||||
Subcellular Localization | Mitochondrion {ECO:0000255HAMAP- Rule:MF_03061}. | ||||||||||||||||||
Disease Associations | Combined oxidative phosphorylation deficiency 1 (COXPD1) [MIM:609060]: A mitochondrial disease resulting in early rapidly progressive hepatoencephalopathy. {ECO:0000269PubMed:15537906, ECO:0000269PubMed:17160893}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000640
Translation elongation factor EFG, V domain IPR000795 Elongation factor, GTP-binding domain IPR004161 Translation elongation factor EFTu/EF1A, domain 2 IPR004540 Translation elongation factor EFG/EF2 IPR005225 Small GTP-binding protein domain IPR005517 Translation elongation factor EFG/EF2, domain IV IPR009000 Translation protein, beta-barrel domain IPR009022 Elongation factor G, III-V domain IPR020568 Ribosomal protein S5 domain 2-type fold IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00679
PF00009 PF03144 PF03764 PF14492 |
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PRINTS |
PR00315
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PIRSF | |||||||||||||||||||
SMART |
SM00838
SM00889 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q96RP9 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q96RP9 | ||||||||||||||||||
TrEMBL | E5KND5 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 85476 | ||||||||||||||||||
UniGene | Hs.686542 | ||||||||||||||||||
RefSeq | NP_079272 | ||||||||||||||||||
HUGO | HGNC:13780 | ||||||||||||||||||
OMIM | 606639 | ||||||||||||||||||
CCDS | CCDS33885 | ||||||||||||||||||
HPRD | 07365 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC025033 AC080013 AF309777 AF367998 AK092293 AK315031 BC049210 CH471052 HQ205226 HQ205227 HQ205229 HQ205230 HQ205231 HQ205234 HQ205237 HQ205238 HQ205240 HQ205241 HQ205243 HQ205244 HQ205245 HQ205247 HQ205248 HQ205249 HQ205251 HQ205252 HQ205255 HQ205258 HQ205261 HQ205262 HQ205263 HQ205264 HQ205265 | ||||||||||||||||||
GenPept | AAH49210 AAK53402 AAK58877 ADP90694 ADP90695 ADP90697 ADP90698 ADP90699 ADP90702 ADP90705 ADP90706 ADP90708 ADP90709 ADP90711 ADP90712 ADP90713 ADP90715 ADP90716 ADP90717 ADP90719 ADP90720 ADP90723 ADP90726 ADP90729 ADP90730 ADP90731 ADP90732 ADP90733 BAG37516 BAG52523 EAW78677 EAW78682 | ||||||||||||||||||