InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HMBS

Summary

InnateDB Gene

IDBG-631690.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMBS

Gene Name

Porphobilinogen deaminase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005364

Encoded Proteins

IDBP-683250

Porphobilinogen deaminase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000256269:
This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:30194980-30202275

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007052

ENSBTAP00000007052

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004418	hydroxymethylbilane synthase activity
GO:0016740	transferase activity

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0018160	peptidyl-pyrromethane cofactor linkage
GO:0033014	tetrapyrrole biosynthetic process