InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HMBS

Summary

InnateDB Protein

IDBP-683250.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMBS

Protein Name

Porphobilinogen deaminase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000007052

InnateDB Gene

IDBG-631690 (HMBS)

Protein Structure

UniProt Annotation

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004418	hydroxymethylbilane synthase activity
GO:0016740	transferase activity

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0018160	peptidyl-pyrromethane cofactor linkage
GO:0033014	tetrapyrrole biosynthetic process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000860 Tetrapyrrole biosynthesis, hydroxymethylbilane synthase
IPR022417 Porphobilinogen deaminase, N-terminal
IPR022418 Porphobilinogen deaminase, C-terminal

PFAM

PF01379
PF03900

PRINTS

PR00151

PIRSF

PIRSF001438

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt