InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ARHGEF2

Summary

InnateDB Gene

IDBG-631807.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF2

Gene Name

rho guanine nucleotide exchange factor 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000113

Encoded Proteins

IDBP-683372

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116584:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:14843522-14868193

Strand

Forward strand

Band

Transcripts

ENSBTAT00000033917

ENSBTAP00000033820

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0017048	Rho GTPase binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0046872	metal ion binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0000902	cell morphogenesis
GO:0007015	actin filament organization
GO:0007026	negative regulation of microtubule depolymerization
GO:0032319	regulation of Rho GTPase activity
GO:0032321	positive regulation of Rho GTPase activity
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050768	negative regulation of neurogenesis
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0071225	cellular response to muramyl dipeptide

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0031982	vesicle
GO:0032587	ruffle membrane
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0043234	protein complex