InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGEF2

Summary

InnateDB Gene

IDBG-103338.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF2

Gene Name

Rho/Rac guanine nucleotide exchange factor (GEF) 2

Synonyms

GEF; GEF-H1; GEFH1; LFP40; P40

Species

Homo sapiens

Ensembl Gene

ENSG00000116584

Encoded Proteins

IDBP-103340

Rho/Rac guanine nucleotide exchange factor (GEF) 2

IDBP-103342

Rho/Rac guanine nucleotide exchange factor (GEF) 2

IDBP-103346

Rho/Rac guanine nucleotide exchange factor (GEF) 2

IDBP-103348

Rho/Rac guanine nucleotide exchange factor (GEF) 2

IDBP-809790

Rho/Rac guanine nucleotide exchange factor (GEF) 2

IDBP-809786

Rho/Rac guanine nucleotide exchange factor (GEF) 2

IDBP-809793

Rho/Rac guanine nucleotide exchange factor (GEF) 2

IDBP-809795

Rho/Rac guanine nucleotide exchange factor (GEF) 2

IDBP-809797

Rho/Rac guanine nucleotide exchange factor (GEF) 2

IDBP-809801

Rho/Rac guanine nucleotide exchange factor (GEF) 2

IDBP-809799

Rho/Rac guanine nucleotide exchange factor (GEF) 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:155946851-156007070

Strand

Reverse strand

Band

q22

Transcripts

ENST00000361247	ENSP00000354837
ENST00000313695	ENSP00000315325
ENST00000368315	ENSP00000357298
ENST00000313667	ENSP00000314787
ENST00000477754
ENST00000470541	ENSP00000476689
ENST00000470975
ENST00000474428
ENST00000462460	ENSP00000476916
ENST00000470874	ENSP00000477448
ENST00000471589	ENSP00000477299
ENST00000476273
ENST00000497907	ENSP00000476724
ENST00000487755
ENST00000465079
ENST00000495070	ENSP00000476532
ENST00000608543
ENST00000609707	ENSP00000476699
ENST00000609126

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0017048	Rho GTPase binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0046872	metal ion binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0000902	cell morphogenesis
GO:0006886	intracellular protein transport
GO:0007015	actin filament organization
GO:0007026	negative regulation of microtubule depolymerization
GO:0007067	mitotic nuclear division
GO:0007264	small GTPase mediated signal transduction
GO:0032319	regulation of Rho GTPase activity
GO:0032321	positive regulation of Rho GTPase activity
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042127	regulation of cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050768	negative regulation of neurogenesis
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060546	negative regulation of necroptotic process
GO:0071225	cellular response to muramyl dipeptide
GO:0071356	cellular response to tumor necrosis factor
GO:0071474	cellular hyperosmotic response
GO:0097190	apoptotic signaling pathway
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005819	spindle
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005923	tight junction
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0031982	vesicle
GO:0032587	ruffle membrane
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0043234	protein complex