Homo sapiens Gene: ARHGEF2
Summary
InnateDB Gene IDBG-103338.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF2
Gene Name Rho/Rac guanine nucleotide exchange factor (GEF) 2
Synonyms GEF; GEF-H1; GEFH1; LFP40; P40;
Species Homo sapiens
Ensembl Gene ENSG00000116584
Encoded Proteins
Rho/Rac guanine nucleotide exchange factor (GEF) 2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155946851-156007070
Strand Reverse strand
Band q22
Transcripts
ENST00000361247 ENSP00000354837
ENST00000313695 ENSP00000315325
ENST00000368315 ENSP00000357298
ENST00000313667 ENSP00000314787
ENST00000477754
ENST00000470541 ENSP00000476689
ENST00000470975
ENST00000474428
ENST00000462460 ENSP00000476916
ENST00000470874 ENSP00000477448
ENST00000471589 ENSP00000477299
ENST00000476273
ENST00000497907 ENSP00000476724
ENST00000487755
ENST00000465079
ENST00000495070 ENSP00000476532
ENST00000608543
ENST00000609707 ENSP00000476699
ENST00000609126
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0017048 Rho GTPase binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0046872 metal ion binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0000902 cell morphogenesis
GO:0006886 intracellular protein transport
GO:0007015 actin filament organization
GO:0007026 negative regulation of microtubule depolymerization
GO:0007067 mitotic nuclear division
GO:0007264 small GTPase mediated signal transduction
GO:0032319 regulation of Rho GTPase activity
GO:0032321 positive regulation of Rho GTPase activity
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042127 regulation of cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050768 negative regulation of neurogenesis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060546 negative regulation of necroptotic process
GO:0071225 cellular response to muramyl dipeptide
GO:0071356 cellular response to tumor necrosis factor
GO:0071474 cellular hyperosmotic response
GO:0097190 apoptotic signaling pathway
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005923 tight junction
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0031982 vesicle
GO:0032587 ruffle membrane
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
TCR pathway
REACTOME
G alpha (12/13) signalling events pathway
Signalling by NGF pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
NRAGE signals death through JNK pathway
Rho GTPase cycle pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
Pathogenic Escherichia coli infection pathway
INOH
PID BIOCARTA
PID NCI
Regulation of RAC1 activity
Reelin signaling pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.743352
RefSeq NM_001162383 NM_001162384 NM_004723
HUGO
OMIM
CCDS CCDS1125 CCDS53375 CCDS53376
HPRD 10458
IMGT
EMBL
GenPept
RNA Seq Atlas