Version 5.4
Bos taurus Gene: BT.88227
Summary
InnateDB Gene IDBG-631905.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.88227
Gene Name iroquois-class homeodomain protein IRX-5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004838
Encoded Proteins
IDBP-683481
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176842:
This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:23309540-23312757
Strand Forward strand
Band
Transcripts
ENSBTAT00000006356 ENSBTAP00000006356
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002027 regulation of heart rate
GO:0006355 regulation of transcription, DNA-templated
GO:0008406 gonad development
GO:0010468 regulation of gene expression
GO:0042551 neuron maturation
GO:0048468 cell development
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0060040 retinal bipolar neuron differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000176842
View Gene Order
ENSMUSG00000031737
View Gene Order
Cross-References
SwissProt
TrEMBL E1B855
UniProt Splice Variant
Entrez Gene 532896
UniGene Bt.88227
RefSeq NM_001192744
HUGO HGNC:14361
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02046472
GenPept
RNA Seq Atlas 532896

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca