InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CLK2

Summary

InnateDB Gene

IDBG-632087.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLK2

Gene Name

dual specificity protein kinase CLK2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014393

Encoded Proteins

IDBP-683755

CDC-like kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176444:
This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have been shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. Note that this gene is distinct from TELO2 gene (GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in common with this gene, but encodes a protein that is involved in telomere length regulation. [provided by RefSeq, Jul 2008]
This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:15422624-15431541

Strand

Forward strand

Band

Transcripts

ENSBTAT00000019139

ENSBTAP00000019139

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0010033	response to organic substance
GO:0010212	response to ionizing radiation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032526	response to retinoic acid
GO:0043484	regulation of RNA splicing
GO:0045721	negative regulation of gluconeogenesis
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000176444

View Gene Order

ENSMUSG00000068917

View Gene Order

Cross-References

SwissProt

TrEMBL

E1B9Q2

UniProt Splice Variant

Entrez Gene

512737

UniGene

RefSeq

NM_001206264 XM_005203698 XM_005203700 XM_005203701

HUGO

HGNC:2069

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02007155

GenPept

RNA Seq Atlas

512737