Homo sapiens Gene: CLK2
Summary
InnateDB Gene IDBG-103224.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLK2
Gene Name CDC-like kinase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000176444
Encoded Proteins
CDC-like kinase 2
CDC-like kinase 2
CDC-like kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have been shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. Note that this gene is distinct from TELO2 gene (GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in common with this gene, but encodes a protein that is involved in telomere length regulation. [provided by RefSeq, Jul 2008]
This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155262868-155278491
Strand Reverse strand
Band q22
Transcripts
ENST00000368361 ENSP00000357345
ENST00000355560 ENSP00000347759
ENST00000361168 ENSP00000354856
ENST00000476983
ENST00000497188
ENST00000471047
ENST00000484699
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0010033 response to organic substance
GO:0010212 response to ionizing radiation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0032526 response to retinoic acid
GO:0043484 regulation of RNA splicing
GO:0045721 negative regulation of gluconeogenesis
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.614471 Hs.73986
RefSeq NM_001294338 NM_003993 XM_005244876 XM_005244878 XM_005276744
HUGO
OMIM
CCDS CCDS1107 CCDS72939
HPRD 04289
IMGT
EMBL
GenPept
RNA Seq Atlas