InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CLK2

Summary

InnateDB Gene

IDBG-103224.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLK2

Gene Name

CDC-like kinase 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000176444

Encoded Proteins

IDBP-103226

CDC-like kinase 2

IDBP-103228

CDC-like kinase 2

IDBP-103230

CDC-like kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have been shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. Note that this gene is distinct from TELO2 gene (GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in common with this gene, but encodes a protein that is involved in telomere length regulation. [provided by RefSeq, Jul 2008]
This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:155262868-155278491

Strand

Reverse strand

Band

q22

Transcripts

ENST00000368361	ENSP00000357345
ENST00000355560	ENSP00000347759
ENST00000361168	ENSP00000354856
ENST00000476983
ENST00000497188
ENST00000471047
ENST00000484699

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.

Experimentally validated
Total	47 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0010033	response to organic substance
GO:0010212	response to ionizing radiation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032526	response to retinoic acid
GO:0043484	regulation of RNA splicing
GO:0045721	negative regulation of gluconeogenesis
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005634	nucleus
GO:0016607	nuclear speck

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000068917

View Gene Order

ENSBTAG00000014393

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.614471 Hs.73986

RefSeq

NM_001294338 NM_003993 XM_005244876 XM_005244878 XM_005276744

HUGO

OMIM

CCDS

CCDS1107 CCDS72939

HPRD

04289

IMGT

EMBL

GenPept

RNA Seq Atlas