Version 5.4
Bos taurus Gene: SCN8A
Summary
InnateDB Gene IDBG-632185.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCN8A
Gene Name sodium channel protein type 8 subunit alpha
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021339
Encoded Proteins
IDBP-683793
sodium channel, voltage gated, type VIII, alpha subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196876:
This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:28211640-28331404
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061543 ENSBTAP00000053165
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005272 sodium channel activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0007517 muscle organ development
GO:0007605 sensory perception of sound
GO:0007626 locomotory behavior
GO:0007628 adult walking behavior
GO:0008344 adult locomotory behavior
GO:0009636 response to toxic substance
GO:0019228 neuronal action potential
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0050905 neuromuscular process
GO:0055085 transmembrane transport
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0034706 sodium channel complex
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000196876
View Gene Order
ENSMUSG00000023033
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MMU9
UniProt Splice Variant
Entrez Gene 537277
UniGene Bt.41157
RefSeq NM_001193102 XM_005206229 XM_005206230
HUGO HGNC:10596
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02012901
GenPept
RNA Seq Atlas 537277

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca