Mus musculus Gene: Scn8a
Summary
InnateDB Gene IDBG-185291.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scn8a
Gene Name sodium channel, voltage-gated, type VIII, alpha
Synonyms AI853486; C630029C19Rik; dmu; med; mnd-2; mnd2; NaCh6; Nav1.6; nmf2; nmf335; nmf58; nur14; seal;
Species Mus musculus
Ensembl Gene ENSMUSG00000023033
Encoded Proteins
sodium channel, voltage-gated, type VIII, alpha
sodium channel, voltage-gated, type VIII, alpha
sodium channel, voltage-gated, type VIII, alpha
sodium channel, voltage-gated, type VIII, alpha
sodium channel, voltage-gated, type VIII, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196876:
This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:100870683-101045929
Strand Forward strand
Band F1
Transcripts
ENSMUST00000096198 ENSMUSP00000093912
ENSMUST00000082209 ENSMUSP00000080842
ENSMUST00000108910 ENSMUSP00000104538
ENSMUST00000108909 ENSMUSP00000104537
ENSMUST00000108908 ENSMUSP00000104536
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0007517 muscle organ development
GO:0007605 sensory perception of sound
GO:0007626 locomotory behavior
GO:0007628 adult walking behavior
GO:0008344 adult locomotory behavior
GO:0009636 response to toxic substance
GO:0019228 neuronal action potential
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0050905 neuromuscular process
GO:0055085 transmembrane transport
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0034706 sodium channel complex
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Interaction between L1 and Ankyrins pathway
Axon guidance pathway
L1CAM interactions pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F7D6H8
UniProt Splice Variant
Entrez Gene 20273
UniGene Mm.385012 Mm.396661 Mm.409617
RefSeq NM_011323 XM_006520651 XM_006520652 XM_006520653 XM_006520654 NM_001077499 XM_006520655 XM_006520656 XM_006520657 XM_006520658
OMIM
CCDS CCDS57011 CCDS57010
HPRD
IMGT
MGI ID MGI:103169
MGI Symbol Scn8a
EMBL AC104833 AC104834
GenPept
RNA Seq Atlas 20273