Bos taurus Gene: SLC6A4
Summary
InnateDB Gene IDBG-632442.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A4
Gene Name sodium-dependent serotonin transporter
Synonyms SERT;
Species Bos taurus
Ensembl Gene ENSBTAG00000019349
Encoded Proteins
sodium-dependent serotonin transporter
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108576:
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:21852431-21872404
Strand Reverse strand
Band
Transcripts
ENSBTAT00000025774 ENSBTAP00000025774
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005335 serotonin:sodium symporter activity
GO:0005515 protein binding
GO:0008504 monoamine transmembrane transporter activity
GO:0015222 serotonin transmembrane transporter activity
GO:0015293 symporter activity
GO:0017137 Rab GTPase binding
GO:0050998 nitric-oxide synthase binding
Biological Process
GO:0006810 transport
GO:0006836 neurotransmitter transport
GO:0006837 serotonin transport
GO:0009636 response to toxic substance
GO:0010628 positive regulation of gene expression
GO:0015844 monoamine transport
GO:0021794 thalamus development
GO:0035176 social behavior
GO:0045787 positive regulation of cell cycle
GO:0046621 negative regulation of organ growth
GO:0048854 brain morphogenesis
GO:0051610 serotonin uptake
GO:0055085 transmembrane transport
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL F1MLI6
UniProt Splice Variant
Entrez Gene 282365
UniGene Bt.4795
RefSeq NM_174609
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02048626
GenPept
RNA Seq Atlas 282365