Version 5.4
Bos taurus Gene: SLC6A4
Summary
InnateDB Gene IDBG-632442.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A4
Gene Name sodium-dependent serotonin transporter
Synonyms SERT
Species Bos taurus
Ensembl Gene ENSBTAG00000019349
Encoded Proteins
IDBP-684061
sodium-dependent serotonin transporter
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108576:
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:21852431-21872404
Strand Reverse strand
Band
Transcripts
ENSBTAT00000025774 ENSBTAP00000025774
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005335 serotonin:sodium symporter activity
GO:0005515 protein binding
GO:0008504 monoamine transmembrane transporter activity
GO:0015222 serotonin transmembrane transporter activity
GO:0015293 symporter activity
GO:0017137 Rab GTPase binding
GO:0050998 nitric-oxide synthase binding
Biological Process
GO:0006810 transport
GO:0006836 neurotransmitter transport
GO:0006837 serotonin transport
GO:0009636 response to toxic substance
GO:0010628 positive regulation of gene expression
GO:0015844 monoamine transport
GO:0021794 thalamus development
GO:0035176 social behavior
GO:0045787 positive regulation of cell cycle
GO:0046621 negative regulation of organ growth
GO:0048854 brain morphogenesis
GO:0051610 serotonin uptake
GO:0055085 transmembrane transport
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000108576
View Gene Order
ENSMUSG00000020838
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.4795
RefSeq NM_174609
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca