Version 5.4
Homo sapiens Gene: SLC6A4
Summary
InnateDB Gene IDBG-38865.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A4
Gene Name solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Synonyms 5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1; SERT; SERT1
Species Homo sapiens
Ensembl Gene ENSG00000108576
Encoded Proteins
IDBP-38867
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
IDBP-240808
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
IDBP-292988
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
IDBP-763020
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:30194319-30236002
Strand Reverse strand
Band q11.2
Transcripts
ENST00000261707 ENSP00000261707
ENST00000394821 ENSP00000378298
ENST00000401766 ENSP00000385822
ENST00000579221 ENSP00000463172
ENST00000578609
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005335 serotonin:sodium symporter activity
GO:0005515 protein binding
GO:0008504 monoamine transmembrane transporter activity
GO:0015222 serotonin transmembrane transporter activity
GO:0017022 myosin binding
GO:0017075 syntaxin-1 binding
GO:0017137 Rab GTPase binding
GO:0019811 cocaine binding
GO:0042803 protein homodimerization activity
GO:0050998 nitric-oxide synthase binding
GO:0051015 actin filament binding
Biological Process
GO:0001666 response to hypoxia
GO:0006836 neurotransmitter transport
GO:0006837 serotonin transport
GO:0007420 brain development
GO:0007584 response to nutrient
GO:0007613 memory
GO:0007623 circadian rhythm
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0010628 positive regulation of gene expression
GO:0015844 monoamine transport
GO:0021794 thalamus development
GO:0021941 negative regulation of cerebellar granule cell precursor proliferation
GO:0032227 negative regulation of synaptic transmission, dopaminergic
GO:0032355 response to estradiol
GO:0035176 social behavior
GO:0042310 vasoconstriction
GO:0042493 response to drug
GO:0042713 sperm ejaculation
GO:0045665 negative regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0046621 negative regulation of organ growth
GO:0048854 brain morphogenesis
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051610 serotonin uptake
GO:0055085 transmembrane transport
GO:0071300 cellular response to retinoic acid
GO:0071310 cellular response to organic substance
GO:0071321 cellular response to cGMP
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0010008 endosome membrane
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020838
View Gene Order
ENSBTAG00000019349
Not yet available
Cross-References
SwissProt P31645
TrEMBL B3VRQ0 B3VRQ5 B3VRR0 B3VRR5 B3VRS0 B3VRS5 B3VRU0 B3VRU5 B3VRV0 B3VRV5 B3VRW0 J3KPR9 Q9NYN7
UniProt Splice Variant
Entrez Gene 6532
UniGene Hs.134662 Hs.29792
RefSeq NM_001045
HUGO HGNC:11050
OMIM 182138
CCDS CCDS11256
HPRD
IMGT
EMBL AC104984 AF233399 AK308014 AY902473 BC069484 EU099989 EU796564 EU796569 EU796574 EU796579 EU796584 EU796589 EU796594 EU796604 EU796609 EU796614 EU796619 EU796624 L05568 U79746 X70697
GenPept AAA35492 AAB93475 AAF61945 AAH69484 AAW80933 ABV02581 ACE96158 ACE96163 ACE96168 ACE96173 ACE96178 ACE96188 ACE96193 ACE96198 ACE96203 ACE96208 ACE96213 ACE96218 CAA50029
RNA Seq Atlas 6532

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca