Version 5.4
| Homo sapiens Gene: PORCN | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-63247.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | PORCN | ||||||||
| Gene Name | porcupine homolog (Drosophila) | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Gene | ENSG00000102312 | ||||||||
| Encoded Proteins |
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the Porc family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome X:48508962-48520814 | ||||||||
| Strand | Forward strand | ||||||||
| Band | p11.23 | ||||||||
| Transcripts | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
Signal Transduction pathway
WNT ligand biogenesis and trafficking pathway
Disease pathway
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| KEGG |
Wnt signaling pathway pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Hs.386453 | ||||||||
| RefSeq | NM_001282167 NM_022825 NM_203473 NM_203474 NM_203475 XM_005272635 XM_005272636 XM_005272637 XM_006724542 XM_006724544 XM_006724546 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | CCDS14296 CCDS14297 CCDS14298 CCDS14299 | ||||||||
| HPRD | 06680 | ||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||