Mus musculus Gene: Porcn
Summary
InnateDB Gene IDBG-130301.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Porcn
Gene Name porcupine homolog (Drosophila)
Synonyms 2410004O13Rik; AW045557; DXHXS7465e; mMg61; Mporc; Mporc-a; Mporc-b; Mporc-c; Mporc-d; porc; Ppn
Species Mus musculus
Ensembl Gene ENSMUSG00000031169
Encoded Proteins
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
porcupine homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102312:
This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the Porc family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:8193848-8206525
Strand Reverse strand
Band A1.1
Transcripts
ENSMUST00000077595 ENSMUSP00000076790
ENSMUST00000082320 ENSMUSP00000080937
ENSMUST00000089403 ENSMUSP00000086825
ENSMUST00000089402 ENSMUSP00000086824
ENSMUST00000154695 ENSMUSP00000138661
ENSMUST00000122943 ENSMUSP00000138626
ENSMUST00000139744
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0009100 glycoprotein metabolic process
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Disease pathway
Signaling by Wnt pathway
WNT ligand biogenesis and trafficking pathway
Signaling by WNT in cancer pathway
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
Signal Transduction pathway
KEGG
Wnt signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
Signal Transduction pathway
WNT ligand biogenesis and trafficking pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9JJJ7
TrEMBL
UniProt Splice Variant
Entrez Gene 53627
UniGene Mm.443425
RefSeq NM_145908 NM_016913 NM_023638 NM_145907
OMIM
CCDS CCDS29993 CCDS29990 CCDS29991 CCDS29992
HPRD
IMGT
MGI ID MGI:1890212
MGI Symbol Porcn
EMBL AB036746 AB036747 AB036748 AB036749 AK010405 AL663032 BC032284
GenPept AAH32284 BAA89467 BAA89468 BAA89469 BAA89470 BAB26914 CAM19505 CAM19507 CAM19508
RNA Seq Atlas 53627