InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HAAO

Summary

InnateDB Gene

IDBG-632937.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HAAO

Gene Name

3-hydroxyanthranilate 3,4-dioxygenase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004674

Encoded Proteins

IDBP-684611

3-hydroxyanthranilate 3,4-dioxygenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162882:
3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:25187252-25201563

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000006132

ENSBTAP00000006132

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000334	3-hydroxyanthranilate 3,4-dioxygenase activity
GO:0005506	iron ion binding
GO:0008198	ferrous iron binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006569	tryptophan catabolic process
GO:0009435	NAD biosynthetic process
GO:0010043	response to zinc ion
GO:0019363	pyridine nucleotide biosynthetic process
GO:0019805	quinolinate biosynthetic process
GO:0034354	'de novo' NAD biosynthetic process from tryptophan
GO:0043420	anthranilate metabolic process
GO:0046686	response to cadmium ion
GO:0055114	oxidation-reduction process
GO:0070050	neuron cellular homeostasis