Homo sapiens Gene: HAAO
Summary
InnateDB Gene IDBG-48645.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAAO
Gene Name 3-hydroxyanthranilate 3,4-dioxygenase
Synonyms 3-HAO; HAO;
Species Homo sapiens
Ensembl Gene ENSG00000162882
Encoded Proteins
3-hydroxyanthranilate 3,4-dioxygenase
3-hydroxyanthranilate 3,4-dioxygenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:42767089-42792593
Strand Reverse strand
Band p21
Transcripts
ENST00000294973 ENSP00000294973
ENST00000406007
ENST00000402698
ENST00000406924
ENST00000402268
ENST00000404451
ENST00000431905 ENSP00000412601
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity
GO:0005506 iron ion binding
GO:0008198 ferrous iron binding
GO:0009055 electron carrier activity
GO:0019825 oxygen binding
GO:0046872 metal ion binding
Biological Process
GO:0006569 tryptophan catabolic process
GO:0010043 response to zinc ion
GO:0019805 quinolinate biosynthetic process
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0034641 cellular nitrogen compound metabolic process
GO:0043420 anthranilate metabolic process
GO:0044281 small molecule metabolic process
GO:0046686 response to cadmium ion
GO:0046874 quinolinate metabolic process
GO:0055114 oxidation-reduction process
GO:0070050 neuron cellular homeostasis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031966 mitochondrial membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Tryptophan catabolism pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
KEGG
Tryptophan metabolism pathway
INOH
Tryptophan degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P46952
TrEMBL C9IY88
UniProt Splice Variant
Entrez Gene 23498
UniGene Hs.368805
RefSeq NM_012205
HUGO HGNC:4796
OMIM 604521
CCDS CCDS33187
HPRD 05158
IMGT
EMBL AC098824 AK295693 BC029510 CH471053 CR457063 CR624693 Z29481
GenPept AAH29510 AAY14701 BAG58544 CAA82618 CAG33344 EAX00309
RNA Seq Atlas 23498