InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: VDR

Summary

InnateDB Gene

IDBG-633008.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VDR

Gene Name

Vitamin D3 receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016414

Encoded Proteins

IDBP-684670

Vitamin D3 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19931640

[Homo sapiens] VDR, vitamin D receptor, deletion leads to reduced level of NFKBIA protein through protein translation, protein-protein interaction, and post-translational modification.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111424:
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:32550521-32606144

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021832

ENSBTAP00000021832

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 100 interaction(s) predicted by orthology.

Predicted by orthology
Total	100 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008434	vitamin D3 receptor activity
GO:0038186	lithocholic acid receptor activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046965	retinoid X receptor binding
GO:0070644	vitamin D response element binding
GO:1902098	calcitriol binding
GO:1902121	lithocholic acid binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000902	cell morphogenesis
GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0007275	multicellular organismal development
GO:0007595	lactation
GO:0008285	negative regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0010628	positive regulation of gene expression
GO:0010839	negative regulation of keratinocyte proliferation
GO:0010980	positive regulation of vitamin D 24-hydroxylase activity
GO:0038183	bile acid signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046697	decidualization
GO:0050892	intestinal absorption
GO:0060058	positive regulation of apoptotic process involved in mammary gland involution
GO:0060558	regulation of calcidiol 1-monooxygenase activity
GO:0060745	mammary gland branching involved in pregnancy