Bos taurus Protein: VDR
Summary
InnateDB Protein IDBP-684670.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VDR
Protein Name Vitamin D3 receptor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000021832
InnateDB Gene IDBG-633008 (VDR)
Protein Structure
UniProt Annotation
Function Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00407}.
Disease Associations
Tissue Specificity Mammary gland, expression increases during lactation. Also found in colon, expression is down-regulated at parturition. {ECO:0000269PubMed:6250480, ECO:0000269PubMed:8747330}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 100 interaction(s) predicted by orthology.
Predicted by orthology
Total 100 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008434 vitamin D3 receptor activity
GO:0038186 lithocholic acid receptor activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046965 retinoid X receptor binding
GO:0070644 vitamin D response element binding
GO:1902098 calcitriol binding
GO:1902121 lithocholic acid binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000902 cell morphogenesis
GO:0001501 skeletal system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0007275 multicellular organismal development
GO:0007595 lactation
GO:0008285 negative regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010839 negative regulation of keratinocyte proliferation
GO:0010980 positive regulation of vitamin D 24-hydroxylase activity
GO:0038183 bile acid signaling pathway
GO:0043401 steroid hormone mediated signaling pathway
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046697 decidualization
GO:0050892 intestinal absorption
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
GO:0060558 regulation of calcidiol 1-monooxygenase activity
GO:0060745 mammary gland branching involved in pregnancy
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000324 Vitamin D receptor
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding
PFAM PF00104
PF00105
PRINTS PR00350
PR00047
PR00398
PIRSF
SMART SM00430
SM00399
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q28037
PhosphoSite PhosphoSite-
TrEMBL Q19MM0
UniProt Splice Variant
Entrez Gene 533656
UniGene Bt.61412
RefSeq NP_001161404
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03056593 DAAA02012986 DQ519355
GenPept ABF68772