Bos taurus Gene: BT.29087
Summary
InnateDB Gene IDBG-633058.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.29087
Gene Name ATP-binding cassette sub-family G member 8
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016366
Encoded Proteins
ATP-binding cassette sub-family G member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143921:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:26156648-26174650
Strand Forward strand
Band
Transcripts
ENSBTAT00000021770 ENSBTAP00000021770
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0017127 cholesterol transporter activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007588 excretion
GO:0010949 negative regulation of intestinal phytosterol absorption
GO:0015914 phospholipid transport
GO:0015918 sterol transport
GO:0033344 cholesterol efflux
GO:0042632 cholesterol homeostasis
GO:0045796 negative regulation of intestinal cholesterol absorption
GO:0055092 sterol homeostasis
Cellular Component
GO:0016020 membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Metabolism of lipids and lipoproteins pathway
ABCA transporters in lipid homeostasis pathway
ABC-family proteins mediated transport pathway
Trafficking of dietary sterols pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
Trafficking of dietary sterols pathway
Metabolism pathway
ABCA transporters in lipid homeostasis pathway
Metabolism of lipids and lipoproteins pathway
Lipid digestion, mobilization, and transport pathway
Transmembrane transport of small molecules pathway
ABC-family proteins mediated transport pathway
KEGG
ABC transporters pathway
Fat digestion and absorption pathway
Bile secretion pathway
ABC transporters pathway
Fat digestion and absorption pathway
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.29087
RefSeq NM_001024663 XM_005212594
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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