Mus musculus Gene: Abcg8
Summary
InnateDB Gene IDBG-200717.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abcg8
Gene Name ATP-binding cassette, sub-family G (WHITE), member 8
Synonyms 1300003C16Rik; AI114946; sterolin-2;
Species Mus musculus
Ensembl Gene ENSMUSG00000024254
Encoded Proteins
ATP-binding cassette, sub-family G (WHITE), member 8
ATP-binding cassette, sub-family G (WHITE), member 8
ATP-binding cassette, sub-family G (WHITE), member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143921:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:84676302-84700333
Strand Forward strand
Band E4
Transcripts
ENSMUST00000045714 ENSMUSP00000035246
ENSMUST00000170725 ENSMUSP00000127785
ENSMUST00000171915 ENSMUSP00000126675
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015248 sterol transporter activity
GO:0016887 ATPase activity
GO:0017127 cholesterol transporter activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006200 ATP catabolic process
GO:0007584 response to nutrient
GO:0007588 excretion
GO:0010949 negative regulation of intestinal phytosterol absorption
GO:0015914 phospholipid transport
GO:0015918 sterol transport
GO:0030299 intestinal cholesterol absorption
GO:0033344 cholesterol efflux
GO:0042493 response to drug
GO:0042632 cholesterol homeostasis
GO:0045796 negative regulation of intestinal cholesterol absorption
GO:0055092 sterol homeostasis
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Trafficking of dietary sterols pathway
Metabolism pathway
ABCA transporters in lipid homeostasis pathway
Metabolism of lipids and lipoproteins pathway
Lipid digestion, mobilization, and transport pathway
Transmembrane transport of small molecules pathway
ABC-family proteins mediated transport pathway
KEGG
ABC transporters pathway
Fat digestion and absorption pathway
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Metabolism of lipids and lipoproteins pathway
ABCA transporters in lipid homeostasis pathway
ABC-family proteins mediated transport pathway
Trafficking of dietary sterols pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
KEGG
ABC transporters pathway
Fat digestion and absorption pathway
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E9Q0P2 Q7TSR6 Q923R9
UniProt Splice Variant
Entrez Gene 67470
UniGene Mm.26581
RefSeq NM_001286005 NM_026180 XM_006524826
OMIM
CCDS CCDS29002 CCDS70849
HPRD
IMGT
MGI ID MGI:1914720
MGI Symbol Abcg8
EMBL AC165360 AF404108 AY196216 BC138484 BC145293
GenPept AAI38485 AAI45294 AAK85391 AAO45096
RNA Seq Atlas 67470