Version 5.4
Bos taurus Gene: RNF5
Summary
InnateDB Gene IDBG-633111.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF5
Gene Name E3 ubiquitin-protein ligase RNF5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000025413
Encoded Proteins
IDBP-684796
E3 ubiquitin-protein ligase RNF5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19285439
[Homo sapiens] RNF5 negatively regulates virus-triggered signaling by targeting TMEM173, an adaptor protein that links virus-sensing receptors to IRF3 activation, for ubiquitination and degradation at the mitochondria.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204308:
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:27012067-27014380
Strand Reverse strand
Band
Transcripts
ENSBTAT00000035701 ENSBTAP00000035571
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0009617 response to bacterium
GO:0010507 negative regulation of autophagy
GO:0016567 protein ubiquitination
GO:0031648 protein destabilization
GO:0044257 cellular protein catabolic process
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0071712 ER-associated misfolded protein catabolic process
GO:2000785 regulation of autophagic vacuole assembly
Cellular Component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000204308
View Gene Order
ENSMUSG00000015478
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N0B8
UniProt Splice Variant
Entrez Gene 616187
UniGene
RefSeq NM_001105445
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02055357
GenPept
RNA Seq Atlas 616187

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca