InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rnf5

Summary

InnateDB Gene

IDBG-172216.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf5

Gene Name

ring finger protein 5

Synonyms

2410131O05Rik; AA407576; NG2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015478

Encoded Proteins

IDBP-172218

ring finger protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19285439

[Homo sapiens] RNF5 negatively regulates virus-triggered signaling by targeting TMEM173, an adaptor protein that links virus-sensing receptors to IRF3 activation, for ubiquitination and degradation at the mitochondria.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204308:
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34601091-34603690

Strand

Reverse strand

Band

Transcripts

ENSMUST00000015622	ENSMUSP00000015622
ENSMUST00000174475
ENSMUST00000174045

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0009617	response to bacterium
GO:0010507	negative regulation of autophagy
GO:0016567	protein ubiquitination
GO:0031648	protein destabilization
GO:0044257	cellular protein catabolic process
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0071712	ER-associated misfolded protein catabolic process
GO:2000785	regulation of autophagic vacuole assembly

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000204308

View Gene Order

ENSBTAG00000025413

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

O35445

TrEMBL

UniProt Splice Variant

Entrez Gene

54197

UniGene

Mm.400900 Mm.412801

RefSeq

NM_019403

OMIM

CCDS

CCDS28650

HPRD

IMGT

MGI ID

MGI:1860076

MGI Symbol

Rnf5

EMBL

AF030001 BC016449

GenPept

AAB82008 AAH16449

RNA Seq Atlas

54197