Mus musculus Gene: Rnf5
Summary
InnateDB Gene IDBG-172216.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf5
Gene Name ring finger protein 5
Synonyms 2410131O05Rik; AA407576; NG2;
Species Mus musculus
Ensembl Gene ENSMUSG00000015478
Encoded Proteins
ring finger protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] RNF5 negatively regulates virus-triggered signaling by targeting TMEM173, an adaptor protein that links virus-sensing receptors to IRF3 activation, for ubiquitination and degradation at the mitochondria.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204308:
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34601091-34603690
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000015622 ENSMUSP00000015622
ENSMUST00000174475
ENSMUST00000174045
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0009617 response to bacterium
GO:0010507 negative regulation of autophagy
GO:0016567 protein ubiquitination
GO:0031648 protein destabilization
GO:0044257 cellular protein catabolic process
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0071712 ER-associated misfolded protein catabolic process
GO:2000785 regulation of autophagic vacuole assembly
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.400900 Mm.412801
RefSeq NM_019403
OMIM
CCDS CCDS28650
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas