Version 5.4
Bos taurus Gene: NT5C3
Summary
InnateDB Gene IDBG-633281.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NT5C3
Gene Name cytosolic 5'-nucleotidase 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016709
Encoded Proteins
IDBP-684979
5'-nucleotidase, cytosolic III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122643:
This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:64185799-64205027
Strand Forward strand
Band
Transcripts
ENSBTAT00000033700 ENSBTAP00000033610
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0008253 5'-nucleotidase activity
Biological Process
GO:0016311 dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000122643
View Gene Order
ENSMUSG00000029780
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_236186
Pyrimidine metabolism pathway
REACT_188937
Metabolism pathway
REACT_241108
Pyrimidine catabolism pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00760
Nicotinate and nicotinamide metabolism pathway
hsa00230
Purine metabolism pathway
mmu00760
Nicotinate and nicotinamide metabolism pathway
mmu00240
Pyrimidine metabolism pathway
mmu00230
Purine metabolism pathway
INOH
INOH website
Nicotinate Nicotinamide metabolism pathway
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.21803
RefSeq NM_001037597 XM_005205470 XM_005205471
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca