InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NT5C3

Summary

InnateDB Gene

IDBG-11769.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NT5C3

Gene Name

5'-nucleotidase, cytosolic III

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000122643

Encoded Proteins

IDBP-11771

5'-nucleotidase, cytosolic III

IDBP-11773

5'-nucleotidase, cytosolic III

IDBP-238095

5'-nucleotidase, cytosolic III

IDBP-294361

5'-nucleotidase, cytosolic III

IDBP-294354

5'-nucleotidase, cytosolic III

IDBP-294349

5'-nucleotidase, cytosolic III

IDBP-371476

5'-nucleotidase, cytosolic III

IDBP-371491

5'-nucleotidase, cytosolic III

IDBP-811462

5'-nucleotidase, cytosolic IIIA

IDBP-811474

5'-nucleotidase, cytosolic IIIA

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:33014114-33062797

Strand

Reverse strand

Band

p14.3

Transcripts

ENST00000381626	ENSP00000371039
ENST00000242210	ENSP00000242210
ENST00000396152	ENSP00000379456
ENST00000405342	ENSP00000385261
ENST00000409467	ENSP00000387166
ENST00000409787	ENSP00000387205
ENST00000456458	ENSP00000389676
ENST00000449201	ENSP00000401161
ENST00000473083
ENST00000461851
ENST00000464840
ENST00000497542
ENST00000610140	ENSP00000476480
ENST00000620705	ENSP00000484415

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0008253	5'-nucleotidase activity
GO:0008665	2'-phosphotransferase activity

Biological Process

GO:0006206	pyrimidine nucleobase metabolic process
GO:0006213	pyrimidine nucleoside metabolic process
GO:0009117	nucleotide metabolic process
GO:0016311	dephosphorylation
GO:0044281	small molecule metabolic process
GO:0046085	adenosine metabolic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029780

View Gene Order

ENSBTAG00000016709

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00240

Pyrimidine metabolism pathway

hsa00760

Nicotinate and nicotinamide metabolism pathway

hsa00230

Purine metabolism pathway

INOH

INOH website

Nicotinate Nicotinamide metabolism pathway

INOH website

Purine nucleotides nucleosides metabolism pathway

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.487933 Hs.605634

RefSeq

NM_001002009 NM_001002010 NM_001166118 NM_016489

HUGO

OMIM

CCDS

CCDS34616 CCDS34617 CCDS55101

HPRD

05871

IMGT

EMBL

GenPept

RNA Seq Atlas