Version 5.4
Bos taurus Gene: IRAK4
Summary
InnateDB Gene IDBG-633310.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRAK4
Gene Name Interleukin-1 receptor-associated kinase 4
Synonyms IRAK-4
Species Bos taurus
Ensembl Gene ENSBTAG00000021105
Encoded Proteins
IDBP-685005
Interleukin-1 receptor-associated kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18794297
[Homo sapiens] IRAK4 is required for interleukin-1 receptor/toll-like receptor-induced MAP3K7 (TAK1)-dependent NF-kappaB activation.
PMID 17997719
[Homo sapiens] IRAK4 and IRAK1 play key roles in a signalling pathway by which bacterial infection or IL-1 trigger the production of inflammatory mediators.
PMID 11923871
[Homo sapiens] IRAK4 is indispensable for the responses of animals and cultured cells to IL-1 and ligands that stimulate various Toll-like receptors (TLRs).
PMID 12682231
[Homo sapiens] IRAK4 plays a critical role in IL-1R and TLR signalling cascades and is an essential component of the IL-18 signalling cascade.
PMID 21220427
[Homo sapiens] IRAK4 activation is impaired during endotoxin tolerization; a process which impairs the production of LPS-induced pro-inflammatory cytokines without inhibition expression of anti-inflammatory or anti-microbial mediators.
PMID 20595480
[Mus musculus] IRAK4-mediated innate immune inflammatory responses play critical roles in divergent clinical outcomes in murine malaria models when Irak4 (-/-) mice were used to study two experimental models of malaria.
PMID 24717937
[Mus musculus] Irak4 activation is impaired during endotoxin tolerization; a process which impairs the production of LPS-induced pro-inflammatory cytokines without inhibition expression of anti-inflammatory or anti-microbial mediators.
PMID 23027530
[Mus musculus] Irak4 deficient mice show impaired innate immunity, leading to defective Type 1 T-cell responses, B-cell expansion, and are more susceptible to Toxoplasma gondii infection.
PMID 24717937
[Mus musculus] Mir302b expression is up-regulated upon bacterial infection and is a crucial regulator of NFκB signalling by directly targeting IRAK4
PMID 25548221
[Mus musculus] Irak4 is a molecular target of chlorogenic acid in the treatment of innate immunity-related shock and organ dysfunction following insult of various Toll-like receptor pathogens from bacteria and viruses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198001:
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:36877863-36905927
Strand Reverse strand
Band
Transcripts
ENSBTAT00000028115 ENSBTAP00000028115
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005149 interleukin-1 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001816 cytokine production
GO:0002376 immune system process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000198001
View Gene Order
ENSMUSG00000059883
View Gene Order
Pathways
NETPATH
REACTOME
REACT_218237
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_222278
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_217035
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_227345
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_210227
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
REACT_210224
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_213612
Cytokine Signaling in Immune system pathway
REACT_213138
Immune System pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_223848
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_225653
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_218091
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_216676
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_219586
MyD88 dependent cascade initiated on endosome pathway
REACT_216714
Innate Immune System pathway
REACT_207826
Interleukin-1 signaling pathway
REACT_206833
Signaling by Interleukins pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_217527
MyD88 cascade initiated on plasma membrane pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_13
IL1 pathway
REACTOME
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25120
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_22442
Interleukin-1 signaling pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_230745
Immune System pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_198527
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_261687
Signaling by Interleukins pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_224208
Interleukin-1 signaling pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
hsa04210
Apoptosis pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa05140
Leishmaniasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa05145
Toxoplasmosis pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu04210
Apoptosis pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu05140
Leishmaniasis pathway
mmu05145
Toxoplasmosis pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
IL-7 signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
il1pathway
IL1-mediated signaling events
toll_endogenous_pathway
Endogenous TLR signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.53276
RefSeq NM_001075998 XM_005206426
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca