Homo sapiens Gene: IRAK4 | |||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-28022.6 | ||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
Gene Symbol | IRAK4 | ||||||||||||||||||||||||||||||||||
Gene Name | interleukin-1 receptor-associated kinase 4 | ||||||||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000198001 | ||||||||||||||||||||||||||||||||||
Encoded Proteins |
interleukin-1 receptor-associated kinase 4
interleukin-1 receptor-associated kinase 4
interleukin-1 receptor-associated kinase 4
interleukin-1 receptor-associated kinase 4
interleukin-1 receptor-associated kinase 4
interleukin-1 receptor-associated kinase 4
interleukin-1 receptor-associated kinase 4
interleukin-1 receptor-associated kinase 4
interleukin-1 receptor-associated kinase 4
interleukin-1 receptor-associated kinase 4
interleukin-1 receptor-associated kinase 4
interleukin-1 receptor-associated kinase 4
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Protein Structure | |||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||||||||
Summary |
IRAK4 is required for interleukin-1 receptor/toll-like receptor-induced MAP3K7 (TAK1)-dependent NF-kappaB activation.
IRAK4 and IRAK1 play key roles in a signalling pathway by which bacterial infection or IL-1 trigger the production of inflammatory mediators.
IRAK4 is indispensable for the responses of animals and cultured cells to IL-1 and ligands that stimulate various Toll-like receptors (TLRs).
IRAK4 plays a critical role in IL-1R and TLR signalling cascades and is an essential component of the IL-18 signalling cascade.
IRAK4 activation is impaired during endotoxin tolerization; a process which impairs the production of LPS-induced pro-inflammatory cytokines without inhibition expression of anti-inflammatory or anti-microbial mediators.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||
Summary |
[Mus musculus] IRAK4-mediated innate immune inflammatory responses play critical roles in divergent clinical outcomes in murine malaria models when Irak4 (-/-) mice were used to study two experimental models of malaria.
[Mus musculus] Irak4 activation is impaired during endotoxin tolerization; a process which impairs the production of LPS-induced pro-inflammatory cytokines without inhibition expression of anti-inflammatory or anti-microbial mediators.
[Mus musculus] Irak4 deficient mice show impaired innate immunity, leading to defective Type 1 T-cell responses, B-cell expansion, and are more susceptible to Toxoplasma gondii infection.
[Mus musculus] Mir302b expression is up-regulated upon bacterial infection and is a crucial regulator of NFκB signalling by directly targeting IRAK4
[Mus musculus] Irak4 is a molecular target of chlorogenic acid in the treatment of innate immunity-related shock and organ dysfunction following insult of various Toll-like receptor pathogens from bacteria and viruses.
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Entrez Gene | |||||||||||||||||||||||||||||||||||
Summary |
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
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Gene Information | |||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 12:43758944-43789543 | ||||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||||
Band | q12 | ||||||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||
NETPATH |
IL1 pathway
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REACTOME |
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Interleukin-1 signaling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
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KEGG |
Apoptosis pathway
Toll-like receptor signaling pathway pathway
Neurotrophin signaling pathway pathway
Leishmaniasis pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
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INOH |
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI |
IL1-mediated signaling events
Endogenous TLR signaling
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Cross-References | |||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||
TrEMBL | F8VVZ1 F8VW24 | ||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
Entrez Gene | 51135 | ||||||||||||||||||||||||||||||||||
UniGene | Hs.138499 | ||||||||||||||||||||||||||||||||||
RefSeq | NM_001114182 NM_001145256 NM_001145257 NM_001145258 NM_016123 XM_005268943 XM_005268944 XM_005268946 XM_005268949 | ||||||||||||||||||||||||||||||||||
HUGO | HGNC:17967 | ||||||||||||||||||||||||||||||||||
OMIM | 606883 | ||||||||||||||||||||||||||||||||||
CCDS | CCDS44862 CCDS8744 | ||||||||||||||||||||||||||||||||||
HPRD | 06051 | ||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||
EMBL | AC093012 | ||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 51135 | ||||||||||||||||||||||||||||||||||