Version 5.4
Bos taurus Gene: NOX1
Summary
InnateDB Gene IDBG-633329.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOX1
Gene Name NADPH oxidase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016761
Encoded Proteins
IDBP-685030
NADPH oxidase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20110267
[Homo sapiens] NOX1 activity is regulated through MAP kinase (MAPK), protein kinase C (PKC), and protein kinase A (PKA)-dependent phosphorylation on Ser-282 and Ser-172 of NOXA1.
PMID 18511861
[Homo sapiens] NOX1 is highly expressed in the colon epithelium and can be induced by LPS or IFN-gamma.
PMID 22120521
[Homo sapiens] NOX1 is essential for reactive oxygen species production in the TLR-mediated innate immune response. NOX1 expression is enhanced by TLR2 signalling through the JAK1/3-STAT3 pathway and is negatively regulated by RGS2. (Demonstrated in mice)
PMID 22120521
[Mus musculus] Nox1 is essential for reactive oxygen species production in the TLR-mediated innate immune response. Nox1 expression is enhanced by Tlr2 signalling through the Jak1/3-Stat3 pathway and is negatively regulated by Rgs2.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000007952:
This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:54668622-54704983
Strand Reverse strand
Band
Transcripts
ENSBTAT00000022291 ENSBTAP00000022291
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016175 superoxide-generating NADPH oxidase activity
GO:0016491 oxidoreductase activity
GO:0030171 voltage-gated proton channel activity
GO:0048365 Rac GTPase binding
Biological Process
GO:0001525 angiogenesis
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0006801 superoxide metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0015992 proton transport
GO:0016477 cell migration
GO:0030198 extracellular matrix organization
GO:0042554 superoxide anion generation
GO:0042743 hydrogen peroxide metabolic process
GO:0043410 positive regulation of MAPK cascade
GO:0045726 positive regulation of integrin biosynthetic process
GO:0046330 positive regulation of JNK cascade
GO:0051454 intracellular pH elevation
GO:0055114 oxidation-reduction process
GO:0071455 cellular response to hyperoxia
GO:0071468 cellular response to acidity
GO:0072592 oxygen metabolic process
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043020 NADPH oxidase complex
GO:0071438 invadopodium membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000007952
View Gene Order
ENSMUSG00000031257
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04670
Leukocyte transendothelial migration pathway
hsa04380
Osteoclast differentiation pathway
hsa04145
Phagosome pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04380
Osteoclast differentiation pathway
mmu04145
Phagosome pathway
INOH
PID NCI
rac1_pathway
RAC1 signaling pathway
Cross-References
SwissProt
TrEMBL E1BPJ7
UniProt Splice Variant
Entrez Gene 521681
UniGene Bt.74528
RefSeq NM_001191340
HUGO HGNC:7889
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02070748 DAAA02070749 DAAA02070750
GenPept
RNA Seq Atlas 521681

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca