Version 5.4
Homo sapiens Gene: NOX1
Summary
InnateDB Gene IDBG-79287.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOX1
Gene Name NADPH oxidase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000007952
Encoded Proteins
IDBP-79289
NADPH oxidase 1
IDBP-79291
NADPH oxidase 1
IDBP-79295
NADPH oxidase 1
IDBP-79297
NADPH oxidase 1
IDBP-377514
NADPH oxidase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20110267
NOX1 activity is regulated through MAP kinase (MAPK), protein kinase C (PKC), and protein kinase A (PKA)-dependent phosphorylation on Ser-282 and Ser-172 of NOXA1.
PMID 18511861
NOX1 is highly expressed in the colon epithelium and can be induced by LPS or IFN-gamma.
PMID 22120521
NOX1 is essential for reactive oxygen species production in the TLR-mediated innate immune response. NOX1 expression is enhanced by TLR2 signalling through the JAK1/3-STAT3 pathway and is negatively regulated by RGS2. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22120521
[Mus musculus] Nox1 is essential for reactive oxygen species production in the TLR-mediated innate immune response. Nox1 expression is enhanced by Tlr2 signalling through the Jak1/3-Stat3 pathway and is negatively regulated by Rgs2.
Entrez Gene
Summary This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:100843324-100874345
Strand Reverse strand
Band q22.1
Transcripts
ENST00000372966 ENSP00000362057
ENST00000372964 ENSP00000362055
ENST00000372960 ENSP00000362051
ENST00000217885 ENSP00000217885
ENST00000427768 ENSP00000396992
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016175 superoxide-generating NADPH oxidase activity
GO:0016491 oxidoreductase activity
GO:0030171 voltage-gated proton channel activity
GO:0046872 metal ion binding
GO:0048365 Rac GTPase binding
GO:0050661 NADP binding
Biological Process
GO:0001525 angiogenesis
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0006739 NADP metabolic process
GO:0006801 superoxide metabolic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell proliferation
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0015992 proton transport
GO:0016477 cell migration
GO:0030198 extracellular matrix organization
GO:0034765 regulation of ion transmembrane transport
GO:0042554 superoxide anion generation
GO:0042743 hydrogen peroxide metabolic process
GO:0043410 positive regulation of MAPK cascade
GO:0045087 innate immune response (InnateDB)
GO:0045726 positive regulation of integrin biosynthetic process
GO:0045730 respiratory burst
GO:0046330 positive regulation of JNK cascade
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051454 intracellular pH elevation
GO:0055114 oxidation-reduction process
GO:0071455 cellular response to hyperoxia
GO:0071468 cellular response to acidity
GO:0072592 oxygen metabolic process
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0043020 NADPH oxidase complex
GO:0071438 invadopodium membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031257
View Gene Order
ENSBTAG00000016761
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04670
Leukocyte transendothelial migration pathway
hsa04380
Osteoclast differentiation pathway
hsa04145
Phagosome pathway
INOH
PID NCI
rac1_pathway
RAC1 signaling pathway
Cross-References
SwissProt Q9Y5S8
TrEMBL
UniProt Splice Variant
Entrez Gene 27035
UniGene
RefSeq NM_013955 NM_001271815 NM_007052
HUGO HGNC:7889
OMIM 300225
CCDS CCDS14475 CCDS14474 CCDS65298
HPRD 02203
IMGT
EMBL AF127763 AF166326 AF166327 AF166328 AK292201 BC075014 BC075015 CH471115 DQ314883 Z83819
GenPept AAD38133 AAF23232 AAF23233 AAF23234 AAH75014 AAH75015 ABC40742 BAF84890 CAI42336 CAI42337 EAX02820
RNA Seq Atlas 27035

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca