InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CTGF

Summary

InnateDB Gene

IDBG-633353.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTGF

Gene Name

Connective tissue growth factor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006367

Encoded Proteins

IDBP-685050

Connective tissue growth factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118523:
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:70873221-70876455

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008357

ENSBTAP00000008357

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0008201	heparin binding

Biological Process

GO:0001502	cartilage condensation
GO:0001503	ossification
GO:0001525	angiogenesis
GO:0001558	regulation of cell growth
GO:0001894	tissue homeostasis
GO:0006260	DNA replication
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010629	negative regulation of gene expression
GO:0016477	cell migration
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0032330	regulation of chondrocyte differentiation
GO:0035988	chondrocyte proliferation
GO:0045597	positive regulation of cell differentiation
GO:0046330	positive regulation of JNK cascade
GO:0051496	positive regulation of stress fiber assembly
GO:0061448	connective tissue development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0072593	reactive oxygen species metabolic process