InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CTGF

Summary

InnateDB Gene

IDBG-96631.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTGF

Gene Name

connective tissue growth factor

Synonyms

CCN2; HCS24; IGFBP8; NOV2

Species

Homo sapiens

Ensembl Gene

ENSG00000118523

Encoded Proteins

IDBP-96633

connective tissue growth factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:131948176-131951373

Strand

Reverse strand

Band

q23.2

Transcripts

ENST00000367976

ENSP00000356954

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	16 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0008083	growth factor activity
GO:0008201	heparin binding

Biological Process

GO:0001502	cartilage condensation
GO:0001503	ossification
GO:0001525	angiogenesis
GO:0001558	regulation of cell growth
GO:0001894	tissue homeostasis
GO:0001934	positive regulation of protein phosphorylation
GO:0006260	DNA replication
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0008544	epidermis development
GO:0009611	response to wounding
GO:0009749	response to glucose
GO:0010260	organ senescence
GO:0010467	gene expression
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010942	positive regulation of cell death
GO:0014070	response to organic cyclic compound
GO:0016477	cell migration
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0032330	regulation of chondrocyte differentiation
GO:0032355	response to estradiol
GO:0032967	positive regulation of collagen biosynthetic process
GO:0034059	response to anoxia
GO:0035556	intracellular signal transduction
GO:0035988	chondrocyte proliferation
GO:0043200	response to amino acid
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043434	response to peptide hormone
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045597	positive regulation of cell differentiation
GO:0046330	positive regulation of JNK cascade
GO:0050867	positive regulation of cell activation
GO:0051385	response to mineralocorticoid
GO:0051496	positive regulation of stress fiber assembly
GO:0060401	cytosolic calcium ion transport
GO:0060452	positive regulation of cardiac muscle contraction
GO:0060548	negative regulation of cell death
GO:0061448	connective tissue development
GO:0070278	extracellular matrix constituent secretion
GO:0070318	positive regulation of G0 to G1 transition
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070542	response to fatty acid
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm