Bos taurus Gene: NOS1 | |||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-633506.3 | ||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
Gene Symbol | NOS1 | ||||||||||||||||||||||||||||||
Gene Name | Nitric oxide synthase | ||||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000002023 | ||||||||||||||||||||||||||||||
Encoded Proteins |
nitric oxide synthase 1 (neuronal)
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Protein Structure | |||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089250:
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011] The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5\' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011] |
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Gene Information | |||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||
Genomic Location | Chromosome 17:60047141-60131472 | ||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||
REACTOME |
Nitric oxide stimulates guanylate cyclase pathway
Platelet homeostasis pathway
Phagosomal maturation (early endosomal stage) pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
Hemostasis pathway
Disease pathway
Platelet homeostasis pathway
Hemostasis pathway
Phagosomal maturation (early endosomal stage) pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Nitric oxide stimulates guanylate cyclase pathway
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KEGG |
Arginine and proline metabolism pathway
Alzheimer's disease pathway
Long-term depression pathway
Calcium signaling pathway pathway
Amyotrophic lateral sclerosis (ALS) pathway
Salivary secretion pathway
Phagosome pathway
Calcium signaling pathway pathway
Alzheimer's disease pathway
Arginine and proline metabolism pathway
Long-term depression pathway
Amyotrophic lateral sclerosis (ALS) pathway
Phagosome pathway
Salivary secretion pathway
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INOH |
Arginine Proline metabolism pathway
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PID NCI | |||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||
UniGene | |||||||||||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||