Bos taurus Gene: FBLN5
Summary
InnateDB Gene IDBG-633579.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBLN5
Gene Name fibulin-5 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018123
Encoded Proteins
fibulin-5 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140092:
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:57153110-57246389
Strand Reverse strand
Band
Transcripts
ENSBTAT00000024122 ENSBTAP00000024122
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0030198 extracellular matrix organization
GO:0034394 protein localization to cell surface
GO:0048251 elastic fiber assembly
GO:2000121 regulation of removal of superoxide radicals
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
GO:0071953 elastic fiber
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Elastic fibre formation pathway
Extracellular matrix organization pathway
Molecules associated with elastic fibres pathway
Elastic fibre formation pathway
Molecules associated with elastic fibres pathway
Extracellular matrix organization pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL Q2KJ89
UniProt Splice Variant
Entrez Gene 535185
UniGene Bt.44183
RefSeq NM_001014946 XM_005222224
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105467 DAAA02053005 DAAA02053006
GenPept AAI05468
RNA Seq Atlas 535185
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)