Mus musculus Gene: Fbln5
Summary
InnateDB Gene IDBG-165156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbln5
Gene Name fibulin 5
Synonyms A55; DANCE; EVEC;
Species Mus musculus
Ensembl Gene ENSMUSG00000021186
Encoded Proteins
fibulin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140092:
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:101746565-101819055
Strand Reverse strand
Band E
Transcripts
ENSMUST00000021603 ENSMUSP00000021603
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0001558 regulation of cell growth
GO:0007155 cell adhesion
GO:0030198 extracellular matrix organization
GO:0034394 protein localization to cell surface
GO:0048251 elastic fiber assembly
GO:2000121 regulation of removal of superoxide radicals
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
GO:0071953 elastic fiber
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Elastic fibre formation pathway
Molecules associated with elastic fibres pathway
Extracellular matrix organization pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Elastic fibre formation pathway
Extracellular matrix organization pathway
Molecules associated with elastic fibres pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9WVH9
TrEMBL
UniProt Splice Variant
Entrez Gene 23876
UniGene Mm.288381
RefSeq NM_011812 XM_006515865 XM_006515866
OMIM
CCDS CCDS36525
HPRD
IMGT
MGI ID MGI:1346091
MGI Symbol Fbln5
EMBL AF112151 AK085170 AK090129 AK159471 AK159960 AK165018 BC006636
GenPept AAD41767 AAH06636 BAC39381 BAC41109 BAE35112 BAE35515 BAE38002
RNA Seq Atlas 23876