InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbln5

Summary

InnateDB Gene

IDBG-165156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbln5

Gene Name

fibulin 5

Synonyms

A55; DANCE; EVEC

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021186

Encoded Proteins

IDBP-165158

fibulin 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140092:
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:101746565-101819055

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021603

ENSMUSP00000021603

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007155	cell adhesion
GO:0030198	extracellular matrix organization
GO:0034394	protein localization to cell surface
GO:0048251	elastic fiber assembly
GO:2000121	regulation of removal of superoxide radicals

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome
GO:0071953	elastic fiber

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000140092

View Gene Order

ENSBTAG00000018123

Not yet available

Pathways

NETPATH

REACTOME

REACT_198996

Elastic fibre formation pathway

REACT_198998

Molecules associated with elastic fibres pathway

REACT_206066

Extracellular matrix organization pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_150331

Molecules associated with elastic fibres pathway

REACT_150366

Elastic fibre formation pathway

REACT_118779

Extracellular matrix organization pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9WVH9

TrEMBL

UniProt Splice Variant

Entrez Gene

23876

UniGene

Mm.288381

RefSeq

NM_011812 XM_006515865 XM_006515866

OMIM

CCDS

CCDS36525

HPRD

IMGT

MGI ID

MGI:1346091

MGI Symbol

Fbln5

EMBL

AF112151 AK085170 AK090129 AK159471 AK159960 AK165018 BC006636

GenPept

AAD41767 AAH06636 BAC39381 BAC41109 BAE35112 BAE35515 BAE38002

RNA Seq Atlas

23876